Dielectric Elastomer Cooperative Microactuator Systems : DECMAS

This paper presents results of the first phase of “Dielectric Elastomer Cooperative Microactuator Systems” (DECMAS), a project within the German Research Foundation Priority Program 2206, “Cooperative Multistable Multistage Microactuator Systems” (KOMMMA). The goal is the development of a soft cooperative microactuator system combining high flexibility with largestroke/high-frequency actuation and self-sensing capabilities. The softness is due to a completely polymer-based approach using dielectric elastomer membrane structures and a specific silicone bias system designed to achieve large strokes. The approach thus avoids fluidic or pneumatic components, enabling, e.g., future smart textile applications with cooperative sensing, haptics, and even acoustic features. The paper introduces design concepts and a first soft, single-actuator demonstrator along with experimental characterization, before expanding it to a 3 × 1 system. This system is used to experimentally study coupling effects, supported by finite element and lumped parameter simulations, which represent the basis for future cooperative control methods. Finally, the paper also introduces a new methodology to fabricate metal-based electrodes of sub-micrometer thickness with high membrane-straining capability and extremely low resistance. These electrodes will enable further miniaturization towards future microscale applications

Finite element modeling and validation of a soft array of spatially coupled dielectric elastomer transducers

Dielectric elastomer (DE) transducers are suitable candidates for the development of compliant mechatronic devices, such as wearable smart skins and soft robots. If many independently-controllable DEs are closely arranged in an array-like configuration, sharing a common elastomer membrane, novel types of cooperative and soft actuator/sensor systems can be obtained. The common elastic substrate, however, introduces strong electro-mechanical coupling effects among neighboring DEs, which highly influence the overall membrane system actuation and sensing characteristics. To effectively design soft cooperative systems based on DEs, these effects need to be systematically understood and modeled first. As a first step towards the development of soft cooperative DE systems, in this paper we present a finite element simulation approach for a 1-by-3 silicone array of DE units. After defining the system constitutive equations and the numerical assumptions, an extensive experimental campaign is conducted to calibrate and validate the model. The simulation results accurately predict the changes in force (actuation behavior) and capacitance (sensing behavior) of the different elements of the array, when their neighbors are subjected to different electro-mechanical loads. Quantitatively, the model reproduces the force and capacitance responses with an average fit higher than 93% and 92%, respectively. Finally, the validated model is used to perform parameter studies, aimed at highlighting how the array performance depends on a relevant set of design parameters, i.e. DE-DE spacing, DE-outer structure spacing, membrane pre-stretch, array scale, and electrode shape. The obtained results will provide important guidelines for the future design of cooperative actuator/sensor systems based on DE transducers

Model-Based Design Optimization of Soft Polymeric Domes Used as Nonlinear Biasing Systems for Dielectric Elastomer Actuators

Due to their unique combination of features such as large deformation, high compliance, lightweight, energy efficiency, and scalability, dielectric elastomer (DE) transducers appear as highly promising for many application fields, such as soft robotics, wearables, as well as micro electromechanical systems (MEMS). To generate a stroke, a membrane DE actuator (DEA) must be coupled with a mechanical biasing system. It is well known that nonlinear elements, such as negative-rate biasing springs (NBS), permit a remarkable increase in the DEA stroke in comparison to standard linear springs. Common types of NBS, however, are generally manufactured with rigid components (e.g., steel beams, permanent magnets), thus they appear as unsuitable for the development of compliant actuators for soft robots and wearables. At the same time, rigid NBSs are hard to miniaturize and integrate in DE-based MEMS devices. This work presents a novel type of soft DEA system, in which a large stroke is obtained by using a fully polymeric dome as the NBS element. More specifically, in this paper we propose a model-based design procedure for high-performance DEAs, in which the stroke is maximized by properly optimizing the geometry of the biasing dome. First, a finite element model of the biasing system is introduced, describing how the geometric parameters of the dome affect its mechanical response. After conducting experimental calibration and validation, the model is used to develop a numerical design algorithm which finds the optimal dome geometry for a given DE membrane characteristics. Based on the optimized dome design, a soft DEA prototype is finally assembled and experimentally tested

Fully Polymeric Domes as High-Stroke Biasing System for Soft Dielectric Elastomer Actuators

The availability of compliant actuators is essential for the development of soft robotic systems. Dielectric elastomers (DEs) represent a class of smart actuators which has gained a significant popularity in soft robotics, due to their unique mix of large deformation (>100%), lightweight, fast response, and low cost. A DE consists of a thin elastomer membrane coated with flexible electrodes on both sides. When a high voltage is applied to the electrodes, the membrane undergoes a controllable mechanical deformation. In order to produce a significant actuation stroke, a DE membrane must be coupled with a mechanical biasing system. Commonly used spring-like bias elements, however, are generally made of rigid materials such as steel, and thus they do not meet the compliance requirements of soft robotic applications. To overcome this issue, in this paper we propose a novel type of compliant mechanism as biasing elements for DE actuators, namely a threedimensional polymeric dome. When properly designed, such types of mechanisms exhibit a region of negative stiffness in their force-displacement behavior. This feature, in combination with the intrinsic softness of the polymeric material, ensures large actuation strokes as well as compliance compatibility with soft robots. After presenting the novel biasing concept, the overall soft actuator design, manufacturing, and assembly are discussed. Finally, experimental characterization is conducted, and the suitability for soft robotic applications is assessed

Electrode Impact on the Electrical Breakdown of Dielectric Elastomer Thin Films

Dielectric Elastomer Actuators (DEAs) enable the realization of energy-efficient and compact actuator systems. DEAs operate at the kilovolt range with typically microampere-level currents and hence minimize thermal losses in comparison to low voltage/high current actuators such as shape memory alloys or solenoids. The main limiting factor for reaching high energy density in high voltage applications is dielectric breakdown. In previous investigations on silicone-based thin films, we reported that not only do environmental conditions and film parameters such as pre-stretch play an important role but that electrode composition also has a significant impact on the breakdown behavior. In this paper, we present a comprehensive study of electrical breakdown on thin silicone films coated with electrodes manufactured by five different methods: screen printing, inkjet printing, pad printing, gold sputtering, and nickel sputtering. For each method, breakdown was studied under environmental conditions ranging from 1 ◦C to 80 ◦C and 10% to 90% relative humidity. The effect of different manufacturing methods was analyzed as was the influence of parameters such as solvents, silicone content, and the particle processing method. The breakdown field increases with increasing temperature and decreases with increasing humidity for all electrode types. The stiffer metal electrodes have a higher breakdown field than the carbon-based electrodes, for which particle size also plays a large role

Entwicklung eines biologischen Pflanzenschutzmittels aus Süßholz mit sicherer Wirkung im Freiland unter Nutzung effizienter Anwendungstechnik; Arbeitsschwerpunkt 1: Industrielle Forschung und Grundlagen

Zusammenfassung Teilprojekt1: Formulierung, Standardisierung und Extraktionsoptimierung In dem Verbundvorhaben sollte ein praxistaugliches Süßholzpräparat entwickelt und damit Anwendungsstrategien gegen Falschen Mehltau und P. infestans im Freiland an Gurke, Tomate bzw. Kartoffel entworfen werden. Diese sollten eine wirksame Regulierung dieser Schlüssel Pathogene ermöglichen und somit die praxisübliche Anwendung von kupferhaltigen Pflanzenschutzmitteln reduzieren oder sogar ersetzen. In dem zu bearbeitenden Teilprojekt von Trifolio-M lag der Schwerpunkt auf der technischen Optimierung des Extraktionsverfahrens und auf der Entwicklung einer wirkungssicheren Formulierung, die in verschiedenen Test Systemen unter Glas, Semi-Freiland und Freilandbedingungen getestet wird. Die bisher entwickelten Formulierungen wiesen trotz vieler Optimierungen keine ausreichende UV- und Regenstabilität für den Einsatz im Freiland auf, folgende Teilziele wurden jedoch erreicht: - Die Wirksamkeit der drei Hauptinhaltsstoffe, die maßgeblich für die befallshemmende Wirkung des Süßholzextraktes verantwortlich sind, wurde bestätigt. - In vitro und in vivo UV-Tests zur Erfassung der UV-Stabilität der optimierten Formulierungen wurden etabliert. - Ausgewählte Formulierungen demonstrierten einen ausreichend stabilen Wirkstoffgehalt während einer simulierten 2-jährigen Lagerung. - Ein im Hinblick auf Energie-, Zeit- und Lösungsmittelbedarf optimiertes Extraktionsverfahren konnte weitestgehend in eine großtechnische Aufbereitung übertragen werden. - Optimierte Formulierungen lassen sich gut mit praxisüblichen Düsen ausbringen. - Der Wirkstoffbedarf konnte in den Formulierungen um 60% gegenüber dem im Rohextrakt gesenkt werden bei gleicher Wirksamkeit im GWH. - Durch die Kontaktwirkung des Süßholzextraktes muss ein hoher Bedeckungsgrad auf den zu schützenden Pflanzenteilen erreicht werden. Die Forschungsarbeiten zur Entwicklung eines Fungizides aus Süßholz werden mit den während des Projektes gewonnenen Erfahrungen z.T. in weiteren nationalen und internationalen Projekten fortgesetzt. -------------------------------------------------------- Zusammenfassung Teilprojekt 2: Wirkungsmechanismen und Vorprüfungen für Freilandanwendungen Im Projekt "Entwicklung eines biologischen Pflanzenschutzmittels aus Süßholz mit sicherer Wirkung im Freiland unter Nutzung effizienter Anwendungstechnik, Arbeitsschwerpunkt 1: Industrielle Forschung und Grundlagen; Teilprojekt 2: Wirkungsmechanismen und Vorprüfungen für Freilandanwendungen“ wurden die UV Beständigkeit formulierter Süßholzextrakte für die weitere Testung im Freiland geprüft (Arbeitsschwerpunkt 2), sowie Untersuchungen zu wirksamen Fraktionen und zum Wirkmechanismus durchgeführt. Formulierungen mit verbesserter Wirkung wurden identifiziert. Bislang konnte jedoch noch keine ausreichend UV-beständige, direkt für die Praxis nutzbare Formulierung gefunden werden. Ergebnisse, die für die weitere Entwicklung des Extraktes bedeutend sind, waren wie folgt: Formulierungen aus Glycyrrhiza glabra-Extrakt (Suspendierbares Konzentrat, 2 % w/v) sollten in Tomaten/Phytophthora infestans mit ca. 800 L/ha ausgebracht werden, um hohe Anfangswirkungen zu erreichen. In Untersuchungen zu wirksamen Fraktionen erreichte Fraktion 4 (Sterole/ Terpenoide) in Gurke/Pseudoperonspora cubensis bei 2,55 % w/v 50 % Wirkungsgrad. Fraktion 6 (Flavonoide) und der Rohextrakt hatten in Tomate eine EC50 von 0,19 % w/v. Für Fraktion 4 wurde in vitro keine sporozide Wirkung gegen P. infestans gezeigt. Fraktion 6 und der Rohextrakt unterdrückten bei 0,1 % w/v (Fraktion 6) bzw. 0,04 % w/v (P1) die Zoosporenentlassung von P. infestans und hatten auch sporozide Wirkung. Welcher Anteil der indirekten Wirkung von Süßholz gegen Oomyceten an der Gesamtwirkung zukommt, ist noch abschließend zu klären. Allerdings scheint die Hauptwirkung ad planta eine direkte zu sein. Rohextrakt, Fraktion 6 und Fraktion 4 hatten eine positive Wirkung auf die physiologische Leistungsfähigkeit der Pflanzen (Chlophyllfluoreszenz-Messungen). Dies zeigte sich in einer Erhöhung der Stresstoleranz gegen biotischen (P. cubensis) bzw. abiotischen Stress (Seneszenz). Letzterer wurde nur für Fraktion 6 und den Rohextrakt geprüft. Insgesamt lag ein pflanzenstärkender Einfluss nach Süßholzbehandlung in Gurke neben der fungistatisch/fungiziden Wirkung des Extraktes vor. Dies erweitert das Anwendungspotential von G. glabra-Extrakt, nicht nur im Pflanzenschutz gegen Oomyceten, sondern auch für die Pflanzenstärkung

Fully Polymeric Domes as High-Stroke Biasing System for Soft Dielectric Elastomer Actuators

The availability of compliant actuators is essential for the development of soft robotic systems. Dielectric elastomers (DEs) represent a class of smart actuators which has gained a significant popularity in soft robotics, due to their unique mix of large deformation (>100%), lightweight, fast response, and low cost. A DE consists of a thin elastomer membrane coated with flexible electrodes on both sides. When a high voltage is applied to the electrodes, the membrane undergoes a controllable mechanical deformation. In order to produce a significant actuation stroke, a DE membrane must be coupled with a mechanical biasing system. Commonly used spring-like bias elements, however, are generally made of rigid materials such as steel, and thus they do not meet the compliance requirements of soft robotic applications. To overcome this issue, in this paper we propose a novel type of compliant mechanism as biasing elements for DE actuators, namely a three-dimensional polymeric dome. When properly designed, such types of mechanisms exhibit a region of negative stiffness in their force-displacement behavior. This feature, in combination with the intrinsic softness of the polymeric material, ensures large actuation strokes as well as compliance compatibility with soft robots. After presenting the novel biasing concept, the overall soft actuator design, manufacturing, and assembly are discussed. Finally, experimental characterization is conducted, and the suitability for soft robotic applications is assessed

Genetic and geographic influence on phenotypic variation in European sarcoidosis patients

IntroductionSarcoidosis is a highly variable disease in terms of organ involvement, type of onset and course. Associations of genetic polymorphisms with sarcoidosis phenotypes have been observed and suggest genetic signatures.MethodsAfter obtaining a positive vote of the competent ethics committee we genotyped 1909 patients of the deeply phenotyped Genetic-Phenotype Relationship in Sarcoidosis (GenPhenReSa) cohort of 31 European centers in 12 countries with 116 potentially disease-relevant single-nucleotide polymorphisms (SNPs). Using a meta-analysis, we investigated the association of relevant phenotypes (acute vs. sub-acute onset, phenotypes of organ involvement, specific organ involvements, and specific symptoms) with genetic markers. Subgroups were built on the basis of geographical, clinical and hospital provision considerations.ResultsIn the meta-analysis of the full cohort, there was no significant genetic association with any considered phenotype after correcting for multiple testing. In the largest sub-cohort (Serbia), we confirmed the known association of acute onset with TNF and reported a new association of acute onset an HLA polymorphism. Multi-locus models with sets of three SNPs in different genes showed strong associations with the acute onset phenotype in Serbia and Lublin (Poland) demonstrating potential region-specific genetic links with clinical features, including recently described phenotypes of organ involvement.DiscussionThe observed associations between genetic variants and sarcoidosis phenotypes in subgroups suggest that gene–environment-interactions may influence the clinical phenotype. In addition, we show that two different sets of genetic variants are permissive for the same phenotype of acute disease only in two geographic subcohorts pointing to interactions of genetic signatures with different local environmental factors. Our results represent an important step towards understanding the genetic architecture of sarcoidosis

Advances in mass spectrometry-based post-column bioaffinity profiling of mixtures

In the screening of complex mixtures, for example combinatorial libraries, natural extracts, and metabolic incubations, different approaches are used for integrated bioaffinity screening. Four major strategies can be used for screening of bioactive mixtures for protein targets—pre-column and post-column off-line, at-line, and on-line strategies. The focus of this review is on recent developments in post-column on-line screening, and the role of mass spectrometry (MS) in these systems. On-line screening systems integrate separation sciences, mass spectrometry, and biochemical methodology, enabling screening for active compounds in complex mixtures. There are three main variants of on-line MS based bioassays: the mass spectrometer is used for ligand identification only; the mass spectrometer is used for both ligand identification and bioassay readout; or MS detection is conducted in parallel with at-line microfractionation with off-line bioaffinity analysis. On the basis of the different fields of application of on-line screening, the principles are explained and their usefulness in the different fields of drug research is critically evaluated. Furthermore, off-line screening is discussed briefly with the on-line and at-line approaches